Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Centromeric chromatin gets loaded.

Christopher W Carroll1, Aaron F Straight

  • 1Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.

The Journal of Cell Biology
|March 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Haplotype-resolved centromeric chromatin organization from a complete diploid human genome.

bioRxiv : the preprint server for biology·2026
Same author

Phosphorylation of Xenopus M18BP1 governs centromeric localization and CENP-A nucleosome assembly.

EMBO reports·2026
Same author

Integrated analysis of multimodal long-read epigenetic assays.

bioRxiv : the preprint server for biology·2025
Same author

Regulation of <i>X. laevis</i> M18BP1 centromeric localization and CENP-A assembly.

bioRxiv : the preprint server for biology·2025
Same author

Histone H3 lysine methyltransferase activities control compartmentalization of human centromeres.

bioRxiv : the preprint server for biology·2025
Same author

Identification of chromatin-associated RNAs at human centromeres.

bioRxiv : the preprint server for biology·2025
Same journal

A pan-vertebrate signaling motif controls the molecular function of intracellular AQP12.

The Journal of cell biology·2026
Same journal

Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.

The Journal of cell biology·2026
Same journal

Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.

The Journal of cell biology·2026
Same journal

Meiotic CENP-C supports centromere assembly and kinetochore recruitment in spermatogenesis.

The Journal of cell biology·2026
Same journal

Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity.

The Journal of cell biology·2026
Same journal

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.

The Journal of cell biology·2026
See all related articles

New research reveals when centromere protein A (CENP-A) is deposited during cell division and identifies a conserved protein essential for this process. These findings enhance our understanding of centromeric chromatin assembly.

Area of Science:

  • Cell Biology
  • Epigenetics
  • Molecular Biology

Background:

  • Centromeric nucleosomes utilize the histone H3 variant, centromere protein A (CENP-A).
  • CENP-A is crucial for kinetochore assembly and accurate chromosome segregation during cell division.

Purpose of the Study:

  • To determine the timing of CENP-A deposition at centromeres throughout the cell cycle.
  • To identify conserved proteins involved in the deposition of CENP-A.

Main Methods:

  • Investigated CENP-A deposition timing using cell division cycle analysis.
  • Employed genetic and biochemical approaches to identify proteins required for CENP-A loading.

Main Results:

  • Two studies elucidate the cell cycle-specific window for CENP-A deposition.

Related Experiment Videos

  • An evolutionarily conserved protein essential for CENP-A loading has been identified.

    • Conclusions:

    • These findings significantly advance the understanding of centromeric chromatin assembly.
    • A framework is provided for future research into the molecular mechanisms of CENP-A loading at centromeres.