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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
N-Benzyltetrahydropyrido-anellated thiophene derivatives: new anticholinesterases
Markus Pietsch1, Martin Nieger, Michael Gütschow
1Pharmaceutical Institute, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
Abstract:
The title compounds, tert-butyl 6-benzyl-2-(3,3-diethylureido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate, C(24)H(33)N(3)O(3)S, (I), 7-benzyl-2-diethylamino-5,6,7,8-tetrahydro-3-oxa-9-thia-1,7-diazafluoren-4-one, C(20)H(23)N(3)O(2)S, (II), and N-(7-benzyl-4-oxo-5,6,7,8-tetrahydro-4H-3,9-dithia-1,7-diazafluoren-2-yl)benzamide, C(23)H(19)N(3)O(2)S(2), (III), form monoclinic crystal systems. In (I) and (II), the molecules are linked into a three-dimensional framework by weak intermolecular C-H...O=C hydrogen bonds, whereas in (III) stronger intermolecular N-H...O=C interactions are observed. The conformation of (I) is further stabilized by an intramolecular N-H...O=C hydrogen bond, which effects the planarity of the ureidothiophenecarboxylate moiety.
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