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Serum amyloid A levels are increased in pre-eclampsia.
Yaprak Engin-Ustün1, Yusuf Ustün, Aysun Bay Karabulut
1Department of Obstetrics and Gynecology, School of Medicine, Inonu University, Malatya, Turkey. ustunyaprak@yahoo.com
Gynecologic and Obstetric Investigation
|March 7, 2007
Summary
Serum amyloid A (SAA) and C-reactive protein (CRP) levels are significantly elevated in pre-eclampsia compared to normal pregnancy. These increased inflammatory markers may play a role in the development of pre-eclampsia.
Area of Science:
- Obstetrics and Gynecology
- Clinical Chemistry
- Immunology
Background:
- Pre-eclampsia is a serious pregnancy complication characterized by high blood pressure.
- Inflammation is increasingly recognized as a key factor in the pathophysiology of pre-eclampsia.
- Biomarkers of inflammation require further investigation for diagnostic and prognostic value.
Purpose of the Study:
- To investigate serum amyloid A (SAA) levels in pregnant women with and without pre-eclampsia.
- To compare SAA levels between normotensive and pre-eclamptic pregnancies.
- To explore the relationship between SAA and C-reactive protein (CRP) in pre-eclampsia.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to quantify SAA levels.
- The study included 25 normotensive pregnant women and 25 pre-eclamptic pregnant women.
- CRP levels were also measured for comparative analysis.
Main Results:
- Serum amyloid A (SAA) levels were significantly higher in pre-eclamptic women (28.2 ng/l) compared to normal pregnant women (7.8 ng/l).
- C-reactive protein (CRP) levels were also significantly elevated in pre-eclampsia (21 mg/l) versus normal pregnancy (6.05 mg/l).
- A positive correlation was observed between SAA and CRP levels in the study population (r = 0.468, p < 0.05).
Conclusions:
- Elevated serum amyloid A (SAA) and C-reactive protein (CRP) are characteristic of pre-eclampsia.
- The inter-relationship between SAA and CRP suggests a role for inflammation in pre-eclampsia pathogenesis.
- These findings highlight SAA and CRP as potential contributors to the inflammatory processes underlying pre-eclampsia.
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