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Updated: Jul 16, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Primary malignant melanoma of the esophagus with multiple esophageal lesions
Khek Yu Ho1, Jun Cheng, Aileen Wee
1Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Singapore. mdchoky@nus.edu.sg
Background:
A 48-year-old Chinese woman presented with a 2-month history of progressive dysphagia for solids, and (less frequently) liquids. She had minimal weight loss and no family history of cancer.
Investigations:
Physical examination, conventional esophagogastroduodenoscopy, CT, fluorodeoxyglucose-PET, endoscopic ultrasonography, and histopathologic examination of excised tumor and biopsy specimens.
Diagnosis:
Primary malignant esophageal melanoma with submucosal infiltration but no distant metastasis.
Management:
Endoscopic polypectomy followed by near-total esophagectomy with esophagogastric anastomosis.
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