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Updated: Jul 16, 2026

Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability
Published on: June 7, 2022
Vascular permeability in ocular disease and the role of tight junctions
Kathryn K Erickson1, Jeffrey M Sundstrom, David A Antonetti
1Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA.
Abstract:
Vascular permeability is closely linked with angiogenesis in a number of pathologies. In the retina, the normally well-developed blood-retinal barrier is altered in a host of eye diseases preceding or commensurate with angiogenesis. This review examines the literature regarding the tight junction complex that establishes the blood-retinal barrier focusing on the transmembrane proteins occludin and the claudin family and the membrane associated protein zonula occludens. The changes observed in these proteins associated with vascular and epithelial permeability is discussed. Finally, novel literature addressing the link between the tight junction complex and angiogenesis is considered.
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