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[Intersexuality in horses].

H Kuiper1, O Distl

  • 1Institut für Tierzucht und Vererbungsforschung, Stiftung Tierärztliche Hochschule Hannover. heidi.kuiper@tiho-hannover.de

DTW. Deutsche Tierarztliche Wochenschrift
|March 8, 2007
PubMed
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Intersexuality in horses is challenging to diagnose. This study identified male pseudohermaphroditism in six cases and suggested SRY-gene deletion as a cause for XY-sex reversal syndrome in equine patients.

Area of Science:

  • Veterinary Science
  • Genetics
  • Reproductive Biology

Context:

  • Intersexuality, a rare congenital anomaly in horses, presents diagnostic challenges due to subtle or absent external reproductive tract abnormalities.
  • This study investigated ten horses with suspected intersexuality or reduced fertility over a five-year period.
  • Utilized a multi-disciplinary diagnostic approach including cytogenetics, molecular genetics, histopathology, and endocrinology.

Purpose:

  • To investigate the underlying causes and identify specific types of intersex conditions in horses with reproductive abnormalities.
  • To apply advanced diagnostic methods to accurately diagnose equine intersexuality.
  • To differentiate between various forms of pseudohermaphroditism and sex reversal syndromes in horses.

Summary:

Related Experiment Videos

  • Cytogenetic and molecular analyses revealed a 64,XX/63,X0 mosaicism in one case.
  • Male pseudohermaphroditism (XY karyotype, testes, and rudimentary female reproductive tract) was confirmed in six horses.
  • Suspected XX-sex reversal and SRY-negative XY-sex reversal syndromes were investigated, with SRY gene deletion being the likely cause for the latter.
  • One case of XX-sex reversal was suspected but not confirmed due to inability to examine gonads, leaving pseudohermaphroditismus femininus as a possibility.

Impact:

  • Provides crucial insights into the complex nature of equine intersexuality.
  • Highlights the importance of integrated diagnostic approaches for accurate identification of reproductive anomalies in horses.
  • Contributes to a better understanding of genetic and hormonal factors influencing sex development in equids.
  • Aids veterinarians in diagnosing and managing cases of reduced fertility and intersex conditions in horses.