Related Experiment Video
Updated: Jul 16, 2026

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
Published on: April 28, 2022
Adding an alcohol-related risk score to an existing categorical risk classification for older adults: sensitivity to
Sandra R Wilson1, Arlene Fink, Shinu Verghese
1Department of Health Services Research, Palo Alto Medical Foundation Research Institute, Palo Alto, California 94301, USA. wilsons@pamfri.org
Objectives:
To evaluate a new alcohol-related risk score for research use.
Design:
Using data from a previously reported trial of a screening and education system for older adults (Computerized Alcohol-Related Problems Survey), secondary analyses were conducted comparing the ability of two different measures of risk to detect post-intervention group differences: the original categorical outcome measure and a new, finely grained quantitative risk score based on the same research-based risk factors.
Setting:
Three primary care group practices in southern California.
Participants:
Six hundred sixty-five patients aged 65 and older.
Measurements:
A previously calculated, three-level categorical classification of alcohol-related risk and a newly developed quantitative risk score.
Results:
Mean post-intervention risk scores differed between the three experimental conditions: usual care, patient report, and combined report (P<.001). The difference between the combined report and usual care was significant (P<.001) and directly proportional to baseline risk. The three-level risk classification did not reveal approximately 57.3% of the intervention effect detected by the risk score. The risk score also was sufficiently sensitive to detect the intervention effect within the subset of hypertensive patients (n=112; P=.001).
Conclusion:
As an outcome measure in intervention trials, the finely grained risk score is more sensitive than the trinary risk classification. The additional clinical value of the risk score relative to the categorical measure needs to be determined.
Related Concept Videos
Hypothesis Test for Test of Independence
H0: The two variables (factors)...
Relative Risk
Pharmacodynamics in Geriatric Patients: Effects of Age
Stereotypes, Prejudice, and Discrimination
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Drug Dosing: Geriatric Patients