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Published on: October 14, 2021

Multicentric Castleman disease with cutaneous manifestations: report of 2 cases and comparison with systemic

Yuko Higashi1, Takuro Kanekura, Ryoko Sakamoto

  • 1Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. higashiy@m.kufm.kagoshima-u.ac.jp

Dermatology (Basel, Switzerland)
|March 8, 2007
PubMed

Insights

Two patients with multicentric Castleman disease presented with skin lesions and enlarged lymph nodes. One patient showed clonal T-cell gene rearrangement, suggesting a potential link to plasma cell disorders.

Area of Science:

  • Hematology
  • Oncology
  • Dermatology

Background:

  • Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder.
  • Understanding the pathogenesis of MCD is crucial for effective treatment strategies.

Observation:

  • Two patients with MCD presented with characteristic skin plaques, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia.
  • Histopathological examination revealed plasma cell and lymphocyte infiltration in skin and lymph nodes.
  • In situ hybridization excluded human herpesvirus 8 and Epstein-Barr virus in skin specimens.

Findings:

  • Polymerase chain reaction (PCR) detected clonal T-cell receptor gene rearrangement in bone marrow cells of one patient.
  • This finding suggests a potential lymphoproliferative component in the disease presentation.

Implications:

  • The study explores the potential relationship between MCD and systemic plasmacytosis.
  • Findings may contribute to a better understanding of plasma cell proliferation in MCD.
  • Further research is warranted to elucidate the role of T-cell clonality in MCD pathogenesis.

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