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A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
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Published on: December 4, 2018

Chronic neutrophilic leukaemia

G G Gan1, J F J Pasagna, G I Eow

  • 1Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. gingingan@yahoo.com

Singapore Medical Journal
|March 8, 2007
PubMed

Chronic neutrophilic leukaemia is a rare myeloproliferative disease characterised by splenomegaly, sustained neutrophilia, raised vitamin B12 level and absence of the Philadelphia chromosome. We report a 74-year-old man who presented first with Sweet's syndrome and subsequently leukocytosis. He had splenomegaly, a raised vitamin B12 level, serum uric acid and neutrophil alkaline phosphatase score. Cytogenetic study of the marrow was normal and peripheral blood for BCR-ABL gene transcript was not detectable. He subsequently passed away with bronchopneumonia.

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