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Candida in acute pancreatitis
Arunaloke Chakrabarti1, Pooja Rao, Bansidhar Tarai
1Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Surgery Today
|March 8, 2007
Summary
Candida infection in acute pancreatitis is increasingly common, affecting 12.2% of patients. Risk factors include severe pancreatic injury and prophylactic fluconazole, leading to longer hospital stays and higher mortality.
Area of Science:
- Medical Mycology
- Gastroenterology
- Infectious Diseases
Background:
- Candida infection of the pancreas was historically rare but is now increasingly reported.
- Understanding the epidemiology and clinical impact of candidal pancreatitis is crucial.
Purpose of the Study:
- To determine the incidence, Candida species, and sites of pancreatic involvement in patients with acute pancreatitis.
- To identify risk factors, severity, and outcomes associated with Candida infection in acute pancreatitis.
Main Methods:
- A cohort analysis of 335 patients with acute pancreatitis was conducted between January 2000 and May 2003.
- Clinical records of patients with confirmed Candida spp. isolation from pancreatic tissue were analyzed.
- A control group of 32 patients negative for Candida spp. was included for comparison.
Main Results:
- Candida infection (true or possible) was observed in 12.2% of patients; Candida tropicalis was the most common species.
- True Candida infection (isolation from pancreatic tissue) occurred in 6.6% of patients.
- Risk factors included severe pancreatic injury, prophylactic fluconazole, and surgery; superinfection led to increased hospital stay and mortality.
Conclusions:
- Candida infection plays a significant role in acute pancreatitis cases.
- Early detection and management of Candida infection in acute pancreatitis are essential.
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