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Effects of hypertension on abdominal wall healing: experimental study in rats
Jair Morais Tostes1, André Luís Watanabe, Luís Massaro Watanabe
1Laboratory of Experimental Surgery, Faculty of Medicine, University of Brasíli, Campus Universitário Darcy Ribeiro, Asa Norte, 70910-900 Brasília-DF, Brazil.
Purpose:
The aim of this study was to investigate the effects of untreated and treated hypertension on abdominal wall healing.
Methods:
Thirty-two spontaneously hypertensive rats (SHR) were randomly allocated into two groups: H (n = 16), untreated and E (n = 16), treated with enalapril (40 mg/kg per day). Group C (n = 16) was a nonhypertensive control group. The animals of each group were submitted to a midline laparotomy and randomly divided, according to the day on which they were killed (7th or 14th postoperative day), into subgroups of 8 animals, as follows: H-7, H-14, E-7, E-14, C-7 and C-14. On the day of their deaths, two strips of the anterior abdominal wall were collected. One strip was submitted to breaking strength measurement and the other to hydroxyproline determination.
Results:
No mortalities or complications were observed in the six subgroups. The breaking strength in E-7 subgroup was significantly lower than in C-7 (P < 0.05). The tissue hydroxyproline levels were similar in all six subgroups (P > 0.05).
Conclusions:
Untreated hypertension had no effect on the abdominal wall healing of rats. Hypertensive animals treated with enalapril showed a significant decrease in abdominal wound-breaking strength on the 7th postoperative day.
