Related Experiment Video
Updated: Jul 16, 2026

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube
Published on: April 28, 2020
[Experimental cirrhosis of the liver obtained with simultaneous carbon tetrachloride and phenobarbital sodium]
P Colombo1, S Savio, M Cavallero
1Laboratorio di Chirurgia Sperimentale e di Fisiopatologia Chirurgica, Istituto di Clinica Chirurgica Generale e Terapia Chirurgica dell'Università di Pavia.
Abstract:
Phenobarbital sodium considerably increases the liver toxicity of CCl4. The onset and course of cirrhosis induced by simultaneous oral phenobarbital sodium and inhaled CCl4 were studied in a large number of rats. The apparatus and method used are described. The results observed are expressed in terms of survival, variations in liver and spleen weight, and the gross and microscopic liver picture. The method is considered for optimal for the rapid induction of marked and typical cirrhosis in the rat.
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