[A morphologic study of the liver of rats with organic phosphorus ester poisoning]

The liver of rats with acute poinsoning by organic phosphorus esters was examined. The poison used was 98% Parathion injected subcutaneously (500 mg per kg) in rats kept on a normal or high-protein diet. The morphologic changes in the liver tissue, and the diminution of the glycogein content and the variations of the protein content were less severe in the rats given a high-protein diet than in those given a diet with a normal protein content. The mechanisms of this pathogenetic correlation in poisoning by organic phosphorus esters are discussed, also in the light of the data reported in the literature.