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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Published on: March 23, 2013
[Clinical study on Tangweikang in treating diabetic gastroparesis]
Rong-Qin Jiang1, De-Xian Zhang, Chun-Ying Bai
1The Fifth People's Hospital of Qingdao City, Shandong. jrq1964@163.com
Objective:
To investigate clinical effects and mechanism of Tangweikang (TWK) in treating diabetic gastroparesis.
Methods:
Ninety diabetic gastroparesis patients were randomly assigned to 3 groups. Besides conventional hypoglycemic treatment, the 30 patients in the treated group were given TWK and the 30 in the control group were given Domperidone additionally, while to the 30 in the blank group, no additional drug was given. The clinical efficacy and the changes in level of motilin and gastric emptying rate were observed.
Results:
TWK showed significant effects in improving clinical symptoms of patients, increasing gastric emptying rate, promoting gastrointestinal kinetics, shortening gastric emptying time and was beneficial to the control of blood sugar, including the 2 h post-prandial blood sugar and fructosamine. The curative rate and total effective rate in the treated group were 63.33% (19/30) and 93.33% (29/30) respectively, significantly different to those in the control group 26.67% (8/30) and 63.33%, also different to those in the blank group 23.33% (3/ 30) and 10.00%, respectively (P < 0.01). The clinical efficacy in the treated group was superior to that in the other two groups.
Conclusion:
TWK has favorable therapeutic efficacy in treating DGP.