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Updated: Jul 16, 2026

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma
Published on: April 25, 2025
[Study on Helicobacter infection in liver tissue from hepatocellular carcinoma]
Ning Li1, Shu-hui Zhang, Shi-ying Xuan
1Qingdao Municipal Hospital, Qingdao 266071, China.
Objective:
To investigate the relationship between Helicobacter species and hepatocellular carcinoma(HCC).
Methods:
Liver samples resected during operation from 34 patients with HCC diagnosed by histopathology and 20 without primary liver carcinoma as controls were studied. The two groups of sample were cranked out pathologic slice for in situ hybridization of Helicobacter, Helicobacter pylori and Helicobacter hepaticus. Qualitative and quantitative studies were used to assess the correlation of liver tissue Helicobacter infection with HCC.
Results:
64.71% (22/34). of the samples of HCC showed positive for Helicobacter specific 16S rRNA-mRNA gene by in situ hybridization, while none was positive in controls (P < 0.01).
Conclusion:
Helicobacter pylori were found in the liver of patients with HCC.
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