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Related Concept Videos

Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Colloids03:22

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the generated carbocation,...
Characteristics and Nomenclature of Copolymers01:24

Characteristics and Nomenclature of Copolymers

Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
Anionic Chain-Growth Polymerization: Mechanism01:04

Anionic Chain-Growth Polymerization: Mechanism

The mechanism for anionic chain-growth polymerization involves initiation, propagation, and termination steps. In the initiation step, a nucleophilic anion, such as butyl lithium, initiates the polymerization process by attacking the π bond of the vinylic monomer. As a result, a carbanion, stabilized by the electron‐withdrawing group, is generated. The resulting carbanion acts as a Michael donor in the propagation step and attacks the second vinylic monomer, which acts as a Michael acceptor.
Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...

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Related Experiment Video

Updated: Jul 16, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Molecule-responsive block copolymer micelles.

Yoshihiro Ishihara1, Hassan S Bazzi, Violeta Toader

  • 1Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, Canada.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|March 9, 2007
PubMed
Summary

Researchers created molecule-responsive micelles using block copolymers. These micelles selectively respond to specific guest molecules, offering potential for targeted drug delivery and sensing applications.

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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

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Published on: July 9, 2015

Area of Science:

  • Polymer Chemistry
  • Supramolecular Chemistry
  • Materials Science

Background:

  • Block copolymers self-assemble into well-defined nanostructures.
  • Noncovalent interactions offer dynamic control over material properties.
  • Molecular recognition is key for targeted applications.

Purpose of the Study:

  • To synthesize and characterize ABC triblock copolymers with specific recognition motifs.
  • To investigate the self-assembly behavior of these copolymers into spherical aggregates.
  • To explore the molecule-responsive nature of these aggregates to guest molecules.

Main Methods:

  • Ring-opening metathesis polymerization (ROMP) for copolymer synthesis.
  • Characterization of copolymer self-assembly into micelles.
  • Investigation of micelle deaggregation triggered by guest molecules.

Main Results:

  • DAP-THY interactions drive the formation of stable spherical aggregates.
  • THY-containing guests induce complete micelle opening and deaggregation.
  • DAP-containing guests lead to the formation of new micelles with altered selectivity.
  • High selectivity observed for guest structure and limited conformational mobility.

Conclusions:

  • Developed guidelines for designing effective molecule-responsive micelles.
  • Demonstrated selective macroscopic response based on guest molecular structure.
  • Highlighted potential applications in drug delivery, sensing, and surface patterning.