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Decreased cerebral glucose utilization in myotonic dystrophy
M Fiorelli1, D Duboc, B M Mazoyer
1Service Hospitalier Frédéric Joliot, CEA, Orsay, France.
Neurology
|January 1, 1992
Summary
Cerebral glucose metabolism is reduced in myotonic dystrophy (MyD) patients, indicating altered brain function. This study used FDG-PET to reveal lower glucose delivery and utilization in the brain for individuals with MyD.
Area of Science:
- Neurology
- Metabolic research
- Neuroimaging
Background:
- Myotonic dystrophy (MyD) is a multisystem disorder.
- Neurologic impairment is a recognized clinical feature of MyD.
- Cerebral metabolic alterations in MyD are not fully understood.
Purpose of the Study:
- To investigate cerebral glucose kinetics and utilization in adult patients with MyD.
- To test the hypothesis that cerebral metabolism is altered in myotonic dystrophy.
- To explore the relationship between metabolic changes and neurologic impairment in MyD.
Main Methods:
- Utilized 18F-labeled 2-fluoro-2-deoxy-D-glucose (FDG) and dynamic positron emission tomography (PET).
- Compared 11 adult patients with MyD against 14 healthy controls.
- Estimated rate constants for glucose metabolism in the brain.
Main Results:
- Reduced FDG delivery to the brain was observed in MyD patients.
- Cortical glucose utilization rate was approximately 20% lower in MyD.
- Findings suggest altered cerebral metabolism in individuals with myotonic dystrophy.
Conclusions:
- Cerebral metabolism is significantly altered in myotonic dystrophy.
- Reduced glucose utilization may underlie neurologic impairment in MyD.
- Further research is warranted to understand brain dysfunction in MyD.