Related Experiment Video

Updated: Jul 16, 2026

Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology
03:33

Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology

Published on: May 23, 2025

Detection rate of Helicobacter pylori stool antigen in newborn infants and small children

Arne Stray-Pedersen1, Peter Gaustad, Babill Stray-Pedersen

  • 1Institute of Forensic Medicine, University of Oslo, Norway. arne.stray-pedersen@labmed.uio.no

Journal of Perinatal Medicine
|March 9, 2007
PubMed

Insights

Helicobacter pylori (H. pylori) antigen was found in over half of Norwegian neonates, suggesting transient colonization. Detection rates decreased significantly in older infants and children.

Area of Science:

  • Microbiology
  • Pediatrics
  • Gastroenterology

Background:

  • Helicobacter pylori infection is a significant global health concern.
  • Understanding H. pylori transmission and colonization in early life is crucial for public health.
  • Previous studies have focused less on neonatal H. pylori prevalence.

Purpose of the Study:

  • To determine the prevalence of H. pylori antigen in stool samples from Norwegian neonates and young children.
  • To explore potential associations between H. pylori antigen detection and factors like age and mode of delivery.

Main Methods:

  • Stool samples were collected from 249 children aged 0 days to 3 years.
  • H. pylori stool antigen test (HpSA) immunoassay was used for detection.
  • Polymerase chain reaction (PCR) targeting the 16S rDNA Helicobacter gene was employed for verification.

Main Results:

  • H. pylori antigen was detected in 52% of neonates, 15% of infants (7 days-1 month), and 5% of children (1 month-3 years).
  • Neonatal H. pylori detection was significantly higher in those born via uncomplicated vaginal birth (59%) compared to Cesarean section (10%).
  • PCR confirmed H. pylori or related species in 35% of HpSA-positive samples.

Conclusions:

  • The high H. pylori antigen prevalence in neonates is unexpected and suggests transient neonatal colonization.
  • Lower H. pylori antigen detection rates in older children align with existing data from Western countries.
  • Further research is warranted to understand the implications of neonatal H. pylori colonization.
Abstract

More Related Videos

Detection of Helicobacter pylori Infection and Antibiotic Resistance via Stool Quantitative Polymerase Chain Reaction Analysis04:56

Detection of Helicobacter pylori Infection and Antibiotic Resistance via Stool Quantitative Polymerase Chain Reaction Analysis

Published on: May 16, 2025

Rapid Detection of Helicobacter pylori Virulence and Typing Using Quantum Dot Labeling Technology05:13

Rapid Detection of Helicobacter pylori Virulence and Typing Using Quantum Dot Labeling Technology

Published on: June 13, 2025

Related Concept Videos

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...