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Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
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Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

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Updated: Jul 16, 2026

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
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Subfecundity in overweight and obese couples.

C H Ramlau-Hansen1, A M Thulstrup, E A Nohr

  • 1Department of Epidemiology, UCLA School of Public Health, University of California-Los Angeles, 650 Charles E. Young Drive S., Los Angeles, CA 90095, USA. craha@as.aaa.dk

Human Reproduction (Oxford, England)
|March 9, 2007
PubMed
Summary

Obesity in either partner negatively impacts couple fecundity, increasing the time to pregnancy. Couples where both partners are obese face a significantly higher risk of subfecundity.

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Published on: March 25, 2021

Area of Science:

  • Reproductive Health
  • Human Reproduction
  • Obesity Research

Background:

  • Growing evidence links male and female obesity to reduced fecundity.
  • Fecundity is a crucial aspect of reproductive health for couples.
  • The study investigates the couple's weight status and its impact on fertility.

Purpose of the Study:

  • To examine the relationship between couple's overweight and obesity and their fecundity.
  • To assess the association between changes in weight over time and fecundity.
  • To understand the combined effect of parental weight on conception.

Main Methods:

  • Utilized data from the Danish National Birth Cohort (1996-2002).
  • Included 47,835 couples with information on Body Mass Index (BMI) and time to pregnancy (TTP).
  • Analyzed BMI and weight changes in relation to subfecundity (TTP > 12 months).

Main Results:

  • A dose-response relationship was observed between increasing BMI and subfecundity in both men and women.
  • Higher BMI in women was associated with increased odds of subfecundity (OR=1.32).
  • Higher BMI in men was also linked to increased odds of subfecundity (OR=1.19).
  • Each kilogram weight gain between pregnancies in women increased TTP by 2.84 days.

Conclusions:

  • Obesity in either partner adversely affects couple fecundity.
  • Couples where both partners are obese have a high risk of subfecundity.
  • Weight management is crucial for optimizing fertility outcomes in couples.