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[Fever--friend or foe?]
1Pediatriska kliniken, Uleåborgs universitet, Uleåborg.
Abstract:
Since the turn of the century intensive research has been carried out to ascertain whether fever is associated with the organism's defence against microbial agents, and evidence is now available concerning the beneficial impact of fever under certain circumstances. However, fever also often gives rise to risks and inimical sequelae. Antipyretics should be used in the correct manner, and when the fever constitutes a hazard to the patient or causes suffering.
Insights
Fever can aid the body's defense against microbes, but it also poses risks. Antipyretics (fever-reducing drugs) should be used cautiously when fever causes harm or distress.
Area of Science:
- Immunology
- Physiology
- Pharmacology
Background:
- Extensive research since 2000 investigates fever's role in host defense against pathogens.
- Evidence suggests fever can be beneficial in certain circumstances.
- However, fever can also lead to adverse effects and complications.
Purpose of the Study:
- To review the dual role of fever in the context of host defense.
- To discuss the risks and benefits associated with fever.
- To provide guidance on the appropriate use of antipyretics.
Main Methods:
- Literature review of studies on fever and host defense.
- Analysis of evidence regarding the beneficial and detrimental effects of fever.
- Examination of clinical guidelines for antipyretic use.
Main Results:
- Fever demonstrates a complex role, offering benefits in combating microbial infections.
- Significant risks and negative consequences can arise from elevated body temperature.
- The decision to use antipyretics requires careful consideration of the patient's condition.
Conclusions:
- Fever is a double-edged sword in host defense, with both advantages and disadvantages.
- Judicious use of antipyretics is crucial, particularly when fever poses a hazard or causes significant discomfort.
- Further research is needed to fully elucidate the mechanisms and optimal management of fever.