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Updated: Jul 16, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Alicyclic diterpenes from solidago species.

F Bohlmann¹, T Chau-Thi, P Singh

¹Institute for Organic Chemistry, Technical University of Berlin Straße des 17. Juni 135, D-1000 Berlin 12.

|December 1, 1985

Summary

Eight new alicyclic diterpenes were identified from Solidago drummondii, with the main compound also found in two other Solidago species. High-field NMR spectroscopy confirmed their structures.

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Area of Science:

Phytochemistry
Natural Product Chemistry
Organic Chemistry

Background:

Solidago species are known sources of diverse chemical compounds.
Alicyclic diterpenes, derived from geranylgeraniol, represent a significant class of natural products with potential bioactivity.

Purpose of the Study:

To isolate and characterize novel alicyclic diterpenes from Solidago drummondii.
To investigate the chemical constituents of other Solidago species for comparison.

Main Methods:

Extraction of aerial parts of Solidago drummondii.
Isolation and purification of compounds using chromatographic techniques.
Structure elucidation of isolated compounds utilizing high-field (1)H-NMR spectroscopy.

Main Results:

Eight alicyclic diterpenes, derived from geranylgeraniol, were identified in Solidago drummondii.
Germacrene D and beta-caryophyllene were also identified as known constituents.
The main constituent was found to be present in Solidago racemosa and Solidago flexicaulis.

Conclusions:

Solidago drummondii is a rich source of unique alicyclic diterpenes.
The structural elucidation confirmed the origin of these compounds from geranylgeraniol.
Comparative analysis revealed the presence of a key compound across multiple Solidago species.