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Related Concept Videos

Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
Antidotes01:17

Antidotes

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Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship01:22

Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
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Related Experiment Videos

[Cardiotonically Active Principles from Spigelia anthelmia1.].

H Wagner1, K Seegert, M P Gupta

  • 1Institut für Pharmazeutische Biologie der Universität München, Karlstr. 29, D-8000 München 2, Bundesrepublik Deutschland.

Planta Medica
|October 1, 1986
PubMed
Summary

Spigelia anthelmia L. contains unique alkaloids, isoquinoline and actinidine-type iridoid, contributing to its cardiotonic effects. Other compounds identified include choline derivatives, supporting its medicinal properties.

Related Experiment Videos

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Natural Products Chemistry

Context:

  • Investigation of the chemical constituents of Spigelia anthelmia L.
  • Focus on identifying bioactive compounds responsible for medicinal properties.
  • Exploration of traditional herbal remedies.

Purpose:

  • To isolate and identify volatile alkaloids from Spigelia anthelmia L.
  • To characterize other chemical compounds present in the water extract.
  • To investigate the role of isolated alkaloids in the plant's cardiotonic activity.

Summary:

  • Two volatile alkaloids, isoquinoline and an actinidine-type iridoid, were isolated from Spigelia anthelmia L.
  • Choline, benzoylcholine, and 3,3-dimethyl-acryloylcholine were identified in the water extract.
  • Preliminary studies suggest these alkaloids are key to the plant's cardiotonic properties.

Impact:

  • Provides insights into the phytochemical profile of Spigelia anthelmia L.
  • Identifies potential therapeutic compounds for cardiovascular applications.
  • Supports the scientific validation of traditional medicinal uses of the plant.