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Related Experiment Videos

Urinary C-peptide in gestational diabetes.

N O Lunell1, B Persson, L Viktorin

  • 1Department of Obstetrics and Gynaecology, Karolinska Institutet, Haddinge University Hospital, Sweden.

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|February 1, 1992
PubMed
Summary

Gestational diabetes is linked to lower daytime urinary C-peptide excretion. This study also found correlations between body mass index and C-peptide in non-diabetic pregnancies.

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Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Pregnancy Research

Background:

  • Gestational diabetes mellitus (GDM) affects maternal and fetal health.
  • Assessing beta-cell function during pregnancy is crucial for GDM management.
  • Urinary C-peptide excretion offers a non-invasive method to evaluate insulin production.

Purpose of the Study:

  • To investigate urinary C-peptide excretion patterns in women with and without gestational diabetes.
  • To explore correlations between C-peptide levels, body mass index, and diabetic heredity.
  • To compare metabolic markers between GDM and control groups.

Main Methods:

  • Urinary C-peptide was measured over 24 hours (daytime and nighttime) in late pregnancy.
  • Fasting plasma samples were analyzed for insulin, C-peptide, glycerol, free fatty acids, and 3-hydroxybutyrate.

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  • Participants included 12 non-diabetic controls and 32 women with gestational diabetes.

    • Main Results:

    • Women with GDM exhibited significantly lower daytime urinary C-peptide excretion.
    • Diabetic heredity was associated with lower C-peptide excretion in GDM patients.
    • Non-diabetic women showed a correlation between BMI and urinary C-peptide.
    • GDM patients had elevated fasting glycerol, free fatty acids, and 3-hydroxybutyrate.

    Conclusions:

    • Reduced daytime C-peptide excretion may indicate altered beta-cell function in gestational diabetes.
    • Metabolic profiles in GDM are characterized by increased lipolysis and ketogenesis.
    • Urinary C-peptide assessment can provide insights into insulin secretion dynamics during pregnancy.