Related Experiment Video
Updated: Jul 16, 2026
08:14
Developing a Clinically Relevant Hemorrhagic Shock Model in Rats
Published on: March 22, 2024
[Post-partum hemorrhage: new therapeutic options]
1Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera, Verona. massimo.franchini@azosp.vr.it
Recenti Progressi in Medicina
|March 10, 2007
Summary
Recombinant activated factor VII (rFVIIa) shows potential for managing severe postpartum hemorrhage unresponsive to standard treatments. Further research is needed to confirm its effectiveness and safety in obstetrical bleeding.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Pharmacology
Context:
- Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality.
- Conventional therapies for PPH are not always effective.
- Recombinant activated factor VII (rFVIIa) is an alternative hemostatic agent.
Purpose:
- To review the existing literature on the use of rFVIIa in managing postpartum hemorrhage.
- To assess the potential role and limitations of rFVIIa in obstetrical bleeding.
Summary:
- rFVIIa, initially for hemophilia, is explored for off-label use in non-hemophilic bleeding, including PPH.
- Published data, though limited and uncontrolled, suggest rFVIIa may help control PPH.
- Optimal dosage, efficacy, and safety of rFVIIa in critical obstetrical bleeding require further investigation.
Impact:
- Highlights the potential of rFVIIa as a treatment option for refractory PPH.
- Identifies the need for robust clinical trials to establish evidence-based guidelines.
- Informs clinical practice regarding the off-label use of rFVIIa in severe postpartum bleeding.
Related Concept Videos
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
01:30Venous Thrombosis IV: Nursing Management
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
01:28Esophageal Varices-II: Clinical Features and Management
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
01:25Cardiopulmonary Resuscitation IV: Pharmacological Management
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...