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A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
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Polyelectrolyte microstructure in chitosan aqueous and alcohol solutions.

N Boucard1, L David, C Rochas

  • 1Laboratoire des Matériaux Polymères et des Biomatériaux, Université de Lyon, Université Lyon 1, UMR CNRS 5223 IMP, 15, Bd. A. Latarjet, Bât. ISTIL, 69622 Villeurbanne Cédex, France.

Biomacromolecules
|March 10, 2007
PubMed
Summary

Chitosan chain ordering in solution was studied using X-ray scattering. Results reveal two distinct organization regimes, "pearl necklace" and "pearl-controlled," depending on chitosan

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Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

Area of Science:

  • Polymer Science
  • Solution Chemistry
  • Biomaterials

Background:

  • Chitosan, a natural polymer, exhibits complex solution behavior influenced by its charge density and hydrophobicity.
  • Understanding polymer chain ordering is crucial for controlling solution properties and material applications.
  • Previous theories on polyelectrolyte organization have not been extensively applied to natural polymers like chitosan.

Purpose of the Study:

  • To investigate the chain ordering of chitosan in aqueous and water-alcohol solutions.
  • To characterize the polyelectrolyte microstructure using small-angle synchrotron X-ray scattering.
  • To explore the influence of degree of acetylation (DA) on chitosan chain organization and solution properties.

Main Methods:

  • Small-angle synchrotron X-ray scattering (SAXS) was employed to study chitosan solutions.
  • The polyelectrolyte microstructure was analyzed by measuring the position of the scattering peak maximum (qmax).
  • The scaling relationship qmax ~ cp^alpha was used to characterize chain ordering as a function of polymer concentration (cp).

Main Results:

  • Two distinct organization regimes were identified, consistent with the Dobrynin and Rubinstein theory.
  • At low DA, chitosan adopts a 'pearl necklace' structure (alpha ~ 1/2), dominated by chain connectivity.
  • At higher DA, a 'pearl-controlled' structure emerges (alpha ~ 1/3), where inter-chain interactions are dominant, influencing the transition to physical gels.

Conclusions:

  • The degree of acetylation (DA) critically controls chitosan chain organization by balancing solvophobic-solvophilic interactions.
  • Parameters like counterion type, solvent composition, and salt concentration significantly affect this interaction balance.
  • The study provides insights into the nanostructure transition from polyelectrolyte solutions to physical gels, depending on gelation conditions.