Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Nuclear Transmutation

Nuclear Transmutation

Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed protons being...

Single-Strand DNA Binding Proteins

Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...

Nuclear Binding Energy

Nuclear Binding Energy

The difference between the calculated and experimentally measured masses is known as the mass defect of the atom. In the case of helium-4, the mass defect indicates a “loss” in mass of 4.0331 amu – 4.0026 amu = 0.0305 amu. The loss in mass accompanying the formation of an atom from protons, neutrons, and electrons is due to the conversion of that mass into energy that is evolved as the atom forms. The nuclear binding energy is the energy produced when the atoms’ nucleons are bound together;...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Easy and versatile preparation of <sup>68</sup>Ga- and Al<sup>18</sup>F-labelled arylphosphonium salts from a common precursor: stability and preliminary in vivo PET/CT evaluation.

EJNMMI radiopharmacy and chemistry·2026

Same author

Recent advances in the antimicrobial potential of boron cluster compounds.

RSC medicinal chemistry·2025

Same author

A new carborane scaffold for assembling metal-organic frameworks.

Chemical communications (Cambridge, England)·2025

Same author

Boron-Based Functionalities Enhance, the Potency of 2,5-Dimethylfuran-Based IDO1 Inhibitors.

Chembiochem : a European journal of chemical biology·2025

Same author

Superior Tumor Cell Uptake by Mono- and Tri-Nuclear Rhodamine-Gadolinium(III) Agents.

Chemistry (Weinheim an der Bergstrasse, Germany)·2024

Same author

Early Stage In Vitro Bioprofiling of Potential Low-Molecular-Weight Organoboron Compounds for Boron Neutron Capture Therapy (BNCT)-Proposal for a Guide.

Cells·2024

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells

Published on: June 9, 2020

Boronated DNA-binding compounds as potential agents for boron neutron capture therapy.

Ellen L Crossley¹, Erin J Ziolkowski, Jeffrey A Coderre

¹School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.

Mini Reviews in Medicinal Chemistry

|March 10, 2007

Summary

Boron Neutron Capture Therapy (BNCT) uses boron and neutrons to destroy cancer cells. Targeting DNA with boron enhances BNCT efficiency, making it a promising cancer treatment strategy.

More Related Videos

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Related Experiment Videos

Last Updated: Jul 16, 2026

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells

Published on: June 9, 2020

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Area of Science:

Oncology
Nuclear Medicine
Medicinal Chemistry

Background:

Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment.
It utilizes nuclear fission of Boron-10 (10B) with thermal neutrons.
BNCT aims to destroy tumor cells via short-range particles.

Purpose of the Study:

To review DNA-binding compounds functionalized with boron for enhanced BNCT.
To explore strategies for improving BNCT efficacy through targeted boron delivery.

Main Methods:

Literature review of DNA-binding agents.
Analysis of boron functionalization in medicinal chemistry.
Assessment of BNCT principles and applications.

Main Results:

DNA-targeted boron delivery significantly enhances BNCT efficiency.
Various DNA-binding scaffolds can be functionalized with boron.
The development of effective boron delivery agents is crucial for BNCT.

Conclusions:

Functionalizing DNA-binding compounds with boron is a key strategy to improve BNCT.
Targeting chromosomal DNA offers a direct route for enhanced tumor cell destruction.
Further research into novel boron delivery agents is warranted for clinical translation.