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Boronated DNA-binding compounds as potential agents for boron neutron capture therapy
Ellen L Crossley1, Erin J Ziolkowski, Jeffrey A Coderre
1School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Abstract:
Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment that exploits the short range particles released from a nuclear fission reaction involving the non-radioactive 10B nucleus and low-energy (thermal) neutrons for the destruction of tumour cells. If boronated agents are targeted towards chromosomal DNA, the efficiency of BNCT is greatly enhanced. This article presents a concise review of DNA-binding compounds that have been functionalised with boron.
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