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Biological evaluation of fluorinated p-boronophenylalanine derivatives as a boron carrier
Yoshihide Hattori1, Kei Kurihara, Hirofumi Kondoh
1Faculty of Science and Technology, Kinki University, Higashi-osaka, Osaka 577-8502, Japan.
Abstract:
Boron neutron capture therapy (BNCT) and magnetic resonance imaging (MRI) are quite attractive techniques for treatment and diagnosis of cancer, respectively. In order to develop practical materials utilizing both for BNCT and MRI, fluorinated p-boronophenylalanines and their alcohol derivatives had already been designed and synthesized. In the present paper the cytotoxicity, the incorporated amount into cancer cells, and the tumor cell killing effects of these compounds were elucidated to evaluate their usefulness as a boron carrier.
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