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Updated: Jul 16, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
White matter microstructural abnormalities in late-life depression
Qiong Yang1, Xuebing Huang, Nan Hong
1Department of Radiology, Peking University People's Hospital, Beijing, China.
Objective:
To evaluate the location and the degree of white matter damage in late-life depression using diffusion tensor imaging (DTI).
Methods:
Thirty-one patients with late-life depression and 15 healthy volunteers matched for age, gender and years of education received conventional MRI (magnetic resonance imaging) and MR-diffusion tensor scanning. The fractional anisotropy (FA) values of white matter were measured respectively in frontal and temporal regions and the corpus callosum.
Results:
FA values were significantly decreased in the frontal (superior and middle frontal gyrus), and temporal (right parahippocampal gyrus) regions of elderly patients with depression compared with healthy controls.
Conclusion:
Microstructural changes in the frontal (superior and middle frontal gyrus) and temporal (right parahippocampal gyrus) areas are associated with late-life depression.
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