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Updated: Jul 16, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

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Published on: January 26, 2024

Evidence for multiple circulating factors in preeclampsia.

Jenny E Myers¹, Sarah Hart, Stuart Armstrong

¹Maternal & Fetal Health Research Centre, The University of Manchester, Manchester, UK. jenny.myers@manchester.ac.uk

American Journal of Obstetrics and Gynecology

|March 10, 2007

Summary

Plasma from women with preeclampsia contains multiple synergistic vasoactive factors. These factors, when combined, negatively impact endothelial function, highlighting a complex interplay in preeclampsia pathophysiology.

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Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

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Published on: January 26, 2024

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Area of Science:

Obstetrics and Gynecology
Cardiovascular Research
Translational Medicine

Background:

Preeclampsia is a serious pregnancy complication characterized by high blood pressure and potential organ damage.
The exact mechanisms underlying preeclampsia pathophysiology, particularly concerning vasoactive factors in plasma, remain incompletely understood.
Identifying and characterizing vasoactive substances in preeclamptic plasma is crucial for understanding disease progression and developing targeted therapies.

Purpose of the Study:

To isolate and identify vasoactive factors present in the plasma of women with preeclampsia.
To determine the specific activity of individual plasma fractions through bioassays.
To investigate the impact of these factors on endothelial function.

Main Methods:

Plasma from preeclamptic women and healthy controls was pooled and fractionated using ultrafiltration, immunodepletion, and size exclusion chromatography.
Myometrial arteries from healthy cesarean section biopsies were used to assess endothelial function via wire myography.
Arteries were incubated with plasma fractions to evaluate their vasoactive effects.

Main Results:

Exposure to preeclamptic plasma, including immunodepleted samples, impaired endothelial-dependent relaxation in myometrial arteries.
Individual fractions obtained through ultrafiltration or size exclusion chromatography showed no bioactivity.
Vasoactive function was restored only when these separated fractions were recombined, indicating the presence of synergistic factors.

Conclusions:

This study provides the first definitive evidence for the existence of multiple synergistic vasoactive factors in the plasma of women with preeclampsia.
These combined factors exert a significant deleterious effect on endothelial function.
The findings underscore the complex, multifactorial nature of preeclampsia's impact on vascular health.