Related Experiment Video
Updated: Jul 16, 2026
High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Published on: January 4, 2015
Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort (Hypericum
Anja Breyer1, Matthias Elstner, Thomas Gillessen
1Institute of Phytopathology, Laboratory of Applied Biochemistry, Technical University of Munich, Munich, Germany.
Abstract:
Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In the above model, cytoprotective effects at a concentration of 0.05% HPE by attenuation of calcium fluxes and cellular energy statuses are reported.
