Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PER3 polymorphism predicts sleep structure and waking performance.

Antoine U Viola1, Simon N Archer, Lynette M James

  • 1Surrey Sleep Research Centre, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK.

Current Biology : CB
|March 10, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential sensitivity of self-reported driving and collision measures to aspects of shiftwork, sleep, and fatigue.

Accident; analysis and prevention·2026
Same author

Diurnal Variation and Impairment of Postprandial Glucose-Insulin Responses and Lipid Rhythms in Simulated Shift Work.

Nutrition bulletin·2026
Same author

Human data at odds and in confirmation of the two-process model of sleep regulation-a perspective.

Npj biological timing and sleep·2026
Same author

Resonance-driven enhancement of sleep spindles using thalamic temporal interference stimulation.

bioRxiv : the preprint server for biology·2026
Same author

Using Legacy Polysomnography Data to Train a Radar System to Quantify Sleep in Older Adults and People living with Dementia.

IEEE transactions on bio-medical engineering·2026
Same author

Chloral Hydrate in the Treatment of Severe Insomnia When Other Treatments Have Failed: Results From a Real-World Evidence Study (RESTORE).

Nature and science of sleep·2026
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

The PERIOD3 gene influences sleep, affecting sleep structure and cognitive performance after sleep loss. This genetic variation impacts sleep homeostasis, not circadian rhythms.

Area of Science:

  • Genetics
  • Sleep Science
  • Chronobiology

Background:

  • Individual differences in sleep-wake regulation are not fully understood.
  • The genetic basis for these differences, particularly concerning sleep homeostasis, remains largely unknown.
  • The PERIOD3 (PER3) gene is implicated in circadian rhythmicity but its role in sleep homeostasis is unclear.

Purpose of the Study:

  • To investigate the impact of a variable-number tandem-repeat polymorphism in the PER3 gene on sleep-wake regulation.
  • To determine if PER3 genotype influences sleep structure and homeostasis.
  • To assess the relationship between PER3 genotype and cognitive performance decrements following sleep deprivation.

Main Methods:

  • Prospective study involving 24 healthy participants selected based on PER3 genotype.

Related Experiment Videos

  • Quantification of sleep structure, including slow-wave sleep (SWS) and electroencephalogram (EEG) activity.
  • Assessment of cognitive performance changes after induced sleep loss.
  • Monitoring of circadian rhythms for melatonin, cortisol, and PER3 mRNA expression.

    • Main Results:

    • PER3 genotype significantly affected sleep structure and markers of sleep homeostasis.
    • Individuals with PER3(5/5) genotype showed increased SWS and EEG slow-wave activity, as well as increased theta and alpha activity during wakefulness and REM sleep.
    • PER3(5/5) individuals experienced a greater decrement in cognitive performance following sleep loss.
    • Circadian rhythms of melatonin, cortisol, and PER3 mRNA were not influenced by the PER3 polymorphism.

    Conclusions:

    • The PER3 gene polymorphism significantly contributes to individual differences in sleep homeostasis.
    • This PER3 variation predicts susceptibility to cognitive performance decline after sleep deprivation.
    • The findings suggest that PER3's effect on sleep homeostasis mediates differential responses to sleep loss.