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Published on: December 4, 2020
Asymptomatic bacteriuria in pregnancy
1Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, McMaster University Medical Centre, Hamilton, Ontario, Canada. smaill@mcmaster.ca <smaill@mcmaster.ca>
Insights
Screening pregnant women for asymptomatic bacteriuria is crucial for preventing pyelonephritis. While treatment may reduce preterm birth, further research is needed to confirm this link and optimize therapy.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Urology
Background:
- Asymptomatic bacteriuria screening is a standard in antenatal care.
- Evidence supports treating asymptomatic bacteriuria to reduce pyelonephritis incidence.
Purpose of the Study:
- To review the evidence for screening and treating asymptomatic bacteriuria in pregnant women.
- To assess the impact of treatment on pyelonephritis, preterm delivery, and low birth weight.
Main Methods:
- Literature review of studies on asymptomatic bacteriuria in pregnancy.
- Analysis of evidence regarding screening methods and treatment efficacy.
Main Results:
- Screening all pregnant women for asymptomatic bacteriuria is recommended.
- Treatment decreases pyelonephritis incidence; potential benefits for preterm birth and low birth weight require cautious interpretation due to study quality.
- Current rapid screening tests are inadequate replacements for urine culture.
Conclusions:
- Continued screening for asymptomatic bacteriuria in pregnancy is supported.
- Further research is necessary to elucidate the mechanism linking treatment to reduced preterm delivery and to establish optimal treatment durations.
Abstract:
Screening for asymptomatic bacteriuria is a standard of obstetrical care and is included in most antenatal guidelines. There is good evidence that treatment of asymptomatic bacteriuria will decrease the incidence of pyelonephritis. All pregnant women should be screened for asymptomatic bacteriuria, and there are no new data that would indicate otherwise. Antibiotic treatment of asymptomatic bacteriuria is associated with a decrease in the incidence of preterm delivery or low birth weight, but the methodological quality of the studies means any conclusion about the strength of this association needs to be drawn cautiously. A better understanding of the mechanism by which treatment of asymptomatic bacteriuria could prevent preterm delivery is needed. While several rapid screening tests have been evaluated, none perform adequately to replace urine culture for detecting asymptomatic bacteriuria. Until there are data from well-designed trials that establish the optimal duration of therapy for asymptomatic bacteriuria, standard treatment courses are recommended.
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