Sarcoidosis of the prostate

Area of Science:

• Urology
• Pathology
• Immunology

Background:

• A 55-year-old man with early-stage prostate cancer underwent prostatectomy.
• Prostate cancer diagnosis and treatment.
• Surgical intervention for prostate cancer.

Observation:

• Incidental finding of non-caseating, epithelioid granulomata adjacent to fibromuscular stroma.
• Granulomata contained Langhans giant cells and rare conchoidal bodies.
• Granuloma distribution differed from typical prostatitis.

Findings:

• Immunohistochemistry showed epithelioid cells positive for angiotensin-converting enzyme.
• Histological findings were suggestive of sarcoidosis.
• Clinical history confirmed sarcoidosis, treated four years prior.

Implications:

• Highlights the importance of considering sarcoidosis in incidental prostate granuloma findings.
• Demonstrates a rare presentation of sarcoidosis in the prostate.
• Emphasizes correlation between histological findings and patient history for accurate diagnosis.