Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stress and the adolescent brain.

Russell D Romeo1, Bruce S McEwen

  • 1Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, New York, NY 10021, USA. romeor@rockefeller.edu

Annals of the New York Academy of Sciences
|March 10, 2007
PubMed
Summary

Adolescent brain plasticity makes it vulnerable to stress. This review examines how stress impacts the pubertal brain and HPA axis, exploring intervention opportunities.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stress-Induced Activation of Orexin-A Neurons in the Lateral Hypothalamus Is Similar in Prepubertal and Adult Male and Female Rats despite Age-Dependent Differences in Hormonal Stress Reactivity.

Neuroendocrinology·2026
Same author

Steroids, stress, and body mass index interact to accelerate female pubertal development.

The Journal of clinical endocrinology and metabolism·2026
Same author

Pubertal- and Stress-Dependent Changes in Cellular Activation and Expression of Excitatory Amino Acid Receptor Subunits in the Paraventricular Nucleus of the Hypothalamus in Male and Female Rats.

Developmental neuroscience·2024
Same author

Early life adversity reduces affiliative behavior with a stressed cagemate and leads to sex-specific alterations in corticosterone responses in adult mice.

Hormones and behavior·2023
Same author

Early life adversity reduces affiliative behavior towards a distressed cagemate and leads to sex-specific alterations in corticosterone responses.

bioRxiv : the preprint server for biology·2023
Same author

Metabolic dysfunctions following chronic oral corticosterone are modified by adolescence and sex in mice.

Physiology & behavior·2023

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Endocrinology

Background:

  • The adolescent brain undergoes significant structural and functional changes.
  • Adolescence represents a critical period of neural plasticity, potentially increasing vulnerability to stressors.
  • Limited understanding exists regarding stress effects on the pubertal brain compared to perinatal and adult stages.

Purpose of the Study:

  • To review current knowledge on pubertal maturation of the hypothalamic-pituitary-adrenal (HPA) axis.
  • To discuss the impact of stressors on the adolescent brain.
  • To explore adolescence as a window for mitigating adverse developmental effects.

Main Methods:

  • Literature review synthesizing existing research on adolescent stress response.
  • Comparative analysis of stress effects in adolescent versus adult brains.
  • Exploration of neuroendocrine and behavioral outcomes related to pubertal stress exposure.

Main Results:

  • The pubertal maturation of the HPA axis is not fully understood.
  • Stressors during adolescence may have long-term consequences, similar to perinatal stress.
  • Adolescent brain plasticity offers potential for therapeutic interventions.

Conclusions:

  • Further research is crucial to understand stress impacts on the developing adolescent brain.
  • Adolescence presents a unique opportunity for interventions to prevent long-term negative health outcomes.
  • Understanding adolescent stress response is key to promoting lifelong well-being.

Related Experiment Videos