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Related Experiment Videos

The function of the epigenome in cell reprogramming.

C Lanzuolo1, V Orlando

  • 1Dulbecco Telethon Institute at Institute of Genetics and Biophysics CNR, Via Pietro Castellino 111, 80131 Naples, Italy.

Cellular and Molecular Life Sciences : CMLS
|March 10, 2007
PubMed
Summary
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The epigenome, encompassing DNA and chromatin modifications, governs gene expression stability and cell identity. Its disruption can cause developmental disorders, cancer, and impact tissue regeneration.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Cellular processes like differentiation and metabolic shifts involve significant gene expression changes.
  • These changes are linked to modifications in chromosomal components, nuclear structures, and DNA/chromatin.
  • These organizational levels collectively define the epigenome, crucial for regulating gene expression.

Purpose of the Study:

  • To elucidate the role of the epigenome in maintaining stable transcription programs.
  • To understand how epigenomic modifications influence cell identity and plasticity.
  • To explore the implications of epigenome perturbation in disease and regeneration.

Main Methods:

  • Analysis of DNA and chromatin modifications.
  • Assessment of chromosomal and nuclear structural organization.

Related Experiment Videos

  • Investigation of gene expression patterns during cellular transitions.

    • Main Results:

    • Epigenomic regulation ensures the stability and heritability of transcription programs.
    • Damage to epigenome components can lead to developmental disorders and cancer.
    • Epigenetic functions are implicated in controlling tissue regeneration and transdifferentiation.

    Conclusions:

    • The epigenome is fundamental to preserving cell identity.
    • The epigenome also provides the molecular basis for cellular plasticity.
    • Understanding epigenomic regulation is key to addressing developmental disorders and cancer, and advancing regenerative medicine.