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Another 'soberade' on the market: does Outox keep its promise?
Marion Pavlic1, Kathrin Libiseller, Petra Grubwieser
1Institute of Legal Medicine, Innsbruck Medical University, Innsbruck, Austria. marion.pavlic@i-med.ac.at
Wiener Klinische Wochenschrift
|March 10, 2007
Summary
This study found that the fructose drink Outox reduced alcohol concentration by about 10% due to slower absorption, not by increasing the alcohol elimination rate. Claims of Outox acting as a "soberade" are scientifically unproven.
Area of Science:
- Pharmacology
- Toxicology
- Human Physiology
Background:
- Fructose-containing beverages are marketed to reduce blood alcohol concentration.
- The proposed mechanism involves enhanced regeneration of NAD+, a coenzyme for alcohol dehydrogenase.
- This effect is theorized to increase the alcohol elimination rate.
Purpose of the Study:
- To investigate the effect of the fructose soft drink Outox on alcohol elimination rate.
- To determine if Outox can reduce alcohol concentration in the body.
- To scientifically validate the claims of Outox as a 'soberade'.
Main Methods:
- A randomized, double-blind, placebo-controlled, cross-over study was conducted with 30 volunteers.
- Participants consumed alcohol followed by either Outox or a placebo under identical conditions.
- Blood (BAC), breath (BrAC), and urine alcohol concentrations (UAC) were measured periodically.
Main Results:
- Outox consumption led to a significant reduction in mean BAC (10.3%) and BrAC (14.3%) compared to placebo.
- The observed differences in alcohol levels were less pronounced in women than in men.
- No significant increase in the alcohol elimination rate (beta 60) was detected.
Conclusions:
- Outox may decrease alcohol concentration by approximately 10%, primarily by slowing gastric absorption.
- The study did not find evidence that Outox increases the alcohol elimination rate.
- Claims of Outox or similar fructose drinks functioning as a 'soberade' lack scientific support; physicians should advise consumers accordingly, especially regarding driving safety.
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