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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Homozygous factor V Leiden mutation and disseminated thrombosis in a patient with nephrotic syndrome

Arzu Kahveci1, Nurhan Seyahi, Emire Seyahi

  • 1Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul - Turkey.

Journal of Nephrology
|March 10, 2007
PubMed

We report the case of a young male patient with nephrotic syndrome and multiple venous thromboses. The patient presented various aggregated thrombophilic risk factors. He was found to be homozygous for factor V Leiden mutation and his anticardiolipin antibody and homocysteine levels were high. The association between nephrotic syndrome and venous thrombosis is well known. However the presence of disseminated thrombosis should prompt an intensive work-up for the detection of thrombotic risk factors and aggressive anticoagulant therapy.

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