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[Studies on using spray drying technique in preparing Ophiopogon japonicus saponin enteric microsphere by orthogonal
Lan Shen1, Yi Feng, De-sheng Xu
1Shanghai University of traditional Chinese medicine, Shanghai 201203, China.
Objective:
To explore the best technique parameters on preparing ophiopogon japonicus saponin enteric microsphere by spray drying technique.
Method:
The best technique parameters were investigated by orthogonal experimental design and by the target, such as surface appearances, encapsulated efficiency, etc.
Result:
The best technique parameters included the inlet temperature (90 degrees C ), the feeding speed (10 mL x min(- 1)), and the rotate speed of atomizer (50 r x min(-1)).
Conclusion:
Ophiopogon japonicus saponin enteric microsphere accorded with the expecting demand. The main influencing factor was inlet temperature . It is suitable to industrialize in preparing Traditional Chinese Medicine microsphere.
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