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Related Experiment Videos

Pathologic correlation in mammographically directed breast biopsies.

D A Symonds1, B E Copeland, A Drane

  • 1Department of Laboratory Medicine, Union Memorial Hospital, Baltimore, MD 21218.

Archives of Pathology & Laboratory Medicine
|January 1, 1992
PubMed
Summary
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Specimen mammography aids breast cancer diagnosis. Calcifications on mammograms often indicate preinvasive carcinoma or significant precursor lesions, improving diagnostic accuracy in biopsies.

Area of Science:

  • Radiology
  • Pathology
  • Oncology

Background:

  • Specimen mammography is crucial for evaluating breast biopsy samples.
  • Understanding the significance of calcifications in these specimens is key for accurate diagnosis.

Purpose of the Study:

  • To assess the diagnostic value of specimen mammography in breast biopsy specimens.
  • To determine the correlation between calcifications and malignancy or precursor lesions.

Main Methods:

  • Analysis of 1137 diagnostic breast biopsy specimens over two years.
  • Performance of specimen mammography on nearly half of the samples (n=534).
  • Correlation of mammographic findings with histopathological diagnoses.

Main Results:

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  • Calcifications were present in 48% of specimen mammograms.
  • Calcifications indicated carcinoma or precursor lesions in 25% of cases, often preinvasive carcinoma.
  • Malignancy yield was lower (12%) in noncalcified specimens.
  • Specimen mammography with radiologist marking aids localization, especially for noncalcified abnormalities.

Conclusions:

  • Specimen mammography is a valuable adjunct in breast biopsy pathology.
  • Calcifications are significant indicators of malignancy or preinvasive disease.
  • Radiologist-pathologist correlation using marked mammograms improves diagnostic yield.