Nested case-control study of energy regulation candidate gene single nucleotide polymorphisms and breast cancer
Yiting Wang1, Marjorie L McCullough, Victoria L Stevens
1Department of Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road NE, Atlanta, Georgia, GA 30329-4251, USA. yiting.wang@cancer.org
Background:
Accumulating evidence suggests that energy regulation, particularly insulin resistance, may influence breast cancer risk.
Materials And Methods:
The associations between single nucleotide polymorphisms (SNPs) in energy regulation candidate genes and postmenopausal breast cancer risk were evaluated. Conditional logistic regression was run on 488 matched case-control pairs from the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. The studied SNPs were INS+1127 PstI (rs3842752), INSR H1085H (rs1799817) and PPARy Prol2Ala (rs1801282).
Results:
A significantly lower breast cancer risk was found among women homozygous for the T allele of INSR H1085H. A marginally significant increased risk of breast cancer was observed among women homozygous for the Ala allele of PPARgamma Pro12Ala. No significant association was observed between INS+ 1127 PstI and breast cancer risk.
Conclusion:
Our results suggest that polymorphisms in these energy regulation candidate genes may be associated with risk of breast cancer, but replication in larger studies is needed.
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

