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Updated: Jul 16, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
The eosinophilic ulcer revisited.
Ourvinder Chawla1, G A Ezra Burke, Andrew D MacBean
1Oral and Maxillofacial Surgery, Maxillofacial Unit, Royal Shrewsbury Hospital, Mytton Oak Road, Shrewsbury, UK.
Eosinophilic ulcers are rare, painful sores on the tongue. This review covers their diagnosis and management, featuring a case study of a young woman with a tongue ulcer.
Area of Science:
- Oral pathology
- Dermatology
- Gastroenterology
Background:
- Eosinophilic ulcer is an uncommon, benign, reactive oral lesion.
- Often presents as a solitary, superficial ulcer with raised borders.
- Etiology is not fully understood but may involve trauma or inflammation.
Observation:
- A case of eosinophilic ulcer on the tongue of a young female patient is presented.
- The lesion was characterized by its clinical appearance and histopathological findings.
- Diagnostic challenges and differential diagnosis considerations are highlighted.
Findings:
- Differential diagnosis involves distinguishing eosinophilic ulcer from other oral ulcerative conditions.
- Histopathology is crucial for definitive diagnosis, showing eosinophilic infiltration.
- Management focuses on symptomatic relief and addressing potential triggers.
Implications:
- Accurate diagnosis prevents unnecessary aggressive treatments for a benign condition.
- Understanding the presentation aids clinicians in recognizing this rare entity.
- Further research may elucidate the specific pathogenetic mechanisms.
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