Related Experiment Video
Updated: Jul 16, 2026
11:27
A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
Published on: November 2, 2018
NF-kappa B signaling and carcinogenesis
Takashi Okamoto1, Takaomi Sanda, Kaori Asamitsu
1Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan. tokamoto@med.nagoya-cu.ac.jp
Current Pharmaceutical Design
|March 14, 2007
Summary
Nuclear factor kappa B (NF-kappaB) is crucial in immune responses and cell regulation, promoting cancer development. Targeting NF-kappaB and its pathways offers a promising anti-cancer strategy.
Area of Science:
- Molecular Biology
- Immunology
- Oncology
Background:
- Nuclear factor kappa B (NF-kappaB) is a key transcription factor regulating genes involved in inflammation, cell cycle, apoptosis, and cell adhesion.
- Dysregulation of NF-kappaB signaling is implicated in carcinogenesis and cancer progression.
- Constitutive NF-kappaB activation is observed in various cancer and leukemia cells, linking chronic inflammation to cancer.
Purpose of the Study:
- To review the role of NF-kappaB in cancer development and progression.
- To discuss the potential of targeting NF-kappaB and its signaling cascade as a novel anti-cancer strategy.
Main Methods:
- Literature review of studies on NF-kappaB in cancer.
- Analysis of NF-kappaB's involvement in oncogenic pathways.
- Discussion of therapeutic strategies targeting NF-kappaB.
Main Results:
- NF-kappaB activation promotes genes that drive cancer initiation and progression.
- Oncogenes and viral proteins can activate the NF-kappaB pathway.
- Chronic inflammation, mediated by NF-kappaB, is linked to carcinogenesis.
Conclusions:
- NF-kappaB plays a significant role in cancer biology.
- Targeting NF-kappaB signaling represents a viable approach for novel anti-cancer therapies.
More Related Videos
Related Concept Videos
02:26NF-κB-dependent Signaling Pathway
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
02:26NF-kB-dependent Signaling Pathway
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
01:20The JAK-STAT Signaling Pathway
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
02:04Co-activators and Co-repressors
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
01:19Interactions Between Signaling Pathways
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...