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Updated: Aug 11, 2026
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
P-31 magnetic resonance spectroscopy in polymyositis and dermatomyositis. Altered energy utilization during exercise
1Department of Rheumatology, Geisinger Medical Center, Danville, Pennsylvania 17822.
Objective:
To explore alterations in energy utilization as a potential etiology for weakness in polymyositis and dermatomyositis (PM/DM).
Methods:
P-31 magnetic resonance spectroscopy studies were performed in patients with acute and treated PM/DM and in normal controls, at rest and with exercise.
Results:
Patients with acute and treated PM/DM showed increased ratios of inorganic phosphate to phosphocreatine (PCr) during exercise, with loss of ATP disproportional to loss of PCr.
Conclusion:
This study demonstrates changes in energy utilization in PM/DM, thus supporting the notion of a metabolic etiology for the weakness associated with these diseases.
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