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Racial differences in the frequencies of scleroderma-related autoantibodies
J D Reveille1, E Durban, R Goldstein
1Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center, Houston.
Objective:
To determine demographic differences in scleroderma-related autoantibodies.
Methods:
One hundred fifty-six patients with systemic sclerosis were prospectively examined for anticentromere antibodies (ACA), anti-topoisomerase I (anti-topo I, or Scl-70), antinucleolar, and anti-U1 RNP autoantibodies.
Results:
ACA was found in 36% of Caucasians and 4% of American blacks (P = 0.002, odds ratio [OR] 15). Anti-topo I was found in 37% of American blacks, compared with 17% of Caucasians (P = 0.04, OR 3). No significant differences in the frequencies of antinucleolar and anti-U1 RNP autoantibodies were found.
Conclusion:
These data suggest important demographic differences in scleroderma-associated autoantibodies.