Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serologic evaluation of patients receiving procainamide.

A B Mongey1, R Donovan-Brand, T J Thomas

  • 1Department of Medicine, University of Cincinnati Medical Center, Ohio 45267.

Arthritis and Rheumatism
|February 1, 1992
PubMed
Summary

Procainamide treatment for cardiac arrhythmias frequently causes antinuclear antibodies and histone antibodies. These serologic abnormalities, linked to procainamide dosage, may indicate an increased risk for drug-related lupus.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advances in our understanding of gout as an auto-inflammatory disease.

Seminars in arthritis and rheumatism·2020
Same author

Application and biomolecular study of functionalized folic acid-dendrimer nanoparticles in drug delivery.

Journal of biomolecular structure & dynamics·2020
Same author

Biodegradable Polymers for Gene Delivery.

Molecules (Basel, Switzerland)·2019
Same author

Cellular and Animal Model Studies on the Growth Inhibitory Effects of Polyamine Analogues on Breast Cancer.

Medical sciences (Basel, Switzerland)·2018
Same author

Design of functionalized folic acid-chitosan nanoparticles for delivery of tetracycline, doxorubicin, and tamoxifen.

Journal of biomolecular structure & dynamics·2018
Same author

Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies.

Cancers·2018

Area of Science:

  • Immunology
  • Cardiology
  • Pharmacology

Background:

  • Procainamide is a common antiarrhythmic drug.
  • Drug-induced lupus is a known adverse effect of certain medications.
  • Serologic abnormalities can precede clinical symptoms of autoimmune diseases.

Purpose of the Study:

  • To investigate the prevalence and characteristics of serologic abnormalities in patients receiving procainamide for cardiac arrhythmias.
  • To determine the association between procainamide use and the development of autoantibodies.
  • To explore potential predictors of drug-related lupus.

Main Methods:

  • Controlled study design.
  • Inclusion of 52 patients on procainamide without connective tissue disease symptoms.

Related Experiment Videos

  • Measurement of antinuclear antibodies (ANA), antibodies to single-stranded DNA (ssDNA), double-stranded DNA (dsDNA), Z-DNA, poly A, and histones (including H2A/2B dimer).

    • Main Results:

    • Antinuclear antibodies (ANA) detected in 83% of patients.
    • Significant elevations in antibodies to ssDNA, dsDNA, Z-DNA, and poly A (P < 0.001).
    • Histone antibodies found in 65.4%, with H2A/2B dimer being most frequent. IgG anti-H2A/2B correlated with procainamide dose. One patient developed drug-related lupus.

    Conclusions:

    • Procainamide therapy is associated with a high incidence of serologic abnormalities, including ANA and histone antibodies.
    • The development of these autoantibodies correlates with procainamide dosage.
    • Monitoring for serologic changes may be important in patients on long-term procainamide treatment.