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Updated: Jul 16, 2026
Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
[Association between vascular endothelial growth factor gene 936 T/C polymorphism and colorectal cancer together with
Guo-Yang Wu1, Xiao-Min Wang, Michael Keese
1Department of General Surgery, Zhongshan Hospital, Xiamen University, Amoy, China.
Objective:
To investigate the association between VEGF gene 936 T/C polymorphism and colorectal cancer together with anastomotic leakage.
Methods:
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the VEGF 936 T/C genotypes in colorectal cancer patients and healthy controls.
Results:
There was no significant difference in the frequency of VEGF 936 C/C genotype or C allele between colorectal cancer patients and healthy controls (P > 0.05). The C/C genotype or C allele in colorectal cancer patients with anastomotic leakage was less frequently found than in the group without anastomotic leakage (P < 0.05).
Conclusions:
VEGF 936 C/C genotype or C allele is not related to the development of colorectal cancer, but they can reduce the risk of anastomotic leakage after surgery in colorectal cancer patients.
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