Related Experiment Video
Updated: Jul 16, 2026
07:09
Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
Role of leptin in immunity
Queenie Lai Kwan Lam1, Liwei Lu
1Department of Pathology and Center of Infection and Immunology, The University of Hong Kong, Hong Kong, China.
Cellular & Molecular Immunology
|March 14, 2007
Summary
Leptin, a hormone regulating metabolism, plays a key role in immune responses and hematopoiesis. This review explores leptin
Area of Science:
- Immunology
- Endocrinology
- Hematopoiesis
Background:
- Leptin, a protein hormone from adipocytes, regulates metabolism and physiological functions.
- Leptin is implicated in immune responses, with increased production during inflammation.
- Leptin signaling deficiency causes dysregulated immune responses and affects hematopoiesis.
Purpose of the Study:
- To review recent advances in understanding leptin's role in immunity.
- To discuss leptin-signaling pathways modulating immune homeostasis.
- To explore leptin's involvement in autoimmune disease pathogenesis.
Main Methods:
- Literature review of recent scientific data and gene-targeting studies.
- Analysis of evidence linking leptin to immune regulation and autoimmune diseases.
- Discussion of leptin-signaling pathways.
Main Results:
- Leptin acts as a pro-inflammatory cytokine, regulating immune responses.
- Leptin is essential for hematopoiesis and lymphopoiesis.
- Growing evidence links leptin to the pathogenesis of autoimmune diseases.
Conclusions:
- Leptin is a critical regulator of immune homeostasis.
- Leptin signaling pathways are key targets for understanding and treating autoimmune diseases.
- Further research into leptin's immunomodulatory functions is warranted.
More Related Videos
05:45Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
10:40Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro
Published on: December 5, 2025
Related Concept Videos
01:28Functions of the Lymphatic and Immune System
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
01:23Introduction to Lymphatic and Immune System
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
01:30Regulation of Food Intake
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
02:26NF-κB-dependent Signaling Pathway
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:31Defense Against Bacterial Pathogens
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...