Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stem cells therapy for type 1 diabetes.

Ping Lü1, Fang Liu, Lei Yan

  • 1Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China. luliu@public.wh.hb.cn

Diabetes Research and Clinical Practice
|March 14, 2007
PubMed
Summary

Stem cell therapy offers potential for type 1 diabetes treatment by generating insulin-producing cells. However, challenges like immune rejection and the need for more research remain before clinical application.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long non-coding RNA H19 contributes to M1 macrophage polarization mediated inflammation via miR-145-5p-PAI-1 axis in systemic lupus erythematosus.

Autoimmunity·2026
Same author

A New Assessment Method of Vitiligo by Combination of Dermoscopy and Reflectance Confocal Microscopy.

Clinical, cosmetic and investigational dermatology·2023
Same author

One-step laparoscopic pancreatic necrosectomy verse surgical step-up approach for infected pancreatic necrosis: a case-control study.

World journal of emergency medicine·2022
Same author

LncRNA-MTA2TR functions as a promoter in pancreatic cancer via driving deacetylation-dependent accumulation of HIF-1α.

Theranostics·2019
Same author

Corrigendum: MiR-148b suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting WNT1/β-catenin pathway.

Scientific reports·2019
Same author

Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription.

Oncogene·2018

Area of Science:

  • Regenerative Medicine
  • Endocrinology
  • Immunology

Background:

  • Type 1 diabetes management is currently limited by islet transplantation scarcity.
  • Stem cell research offers a potential solution for a limitless supply of insulin-producing cells.

Purpose of the Study:

  • To review advancements in stem cell therapy for type 1 diabetes.
  • To explore the potential of stem/progenitor cells in generating insulin-producing cells for replacement therapy.
  • To identify current challenges and future directions in the field.

Main Methods:

  • Literature review using PubMed and analysis of existing studies.
  • Evaluation of evidence for stem/progenitor cell differentiation into insulin-producing cells.
  • Assessment of challenges in autoimmune suppression and tolerance induction.

Related Experiment Videos

Main Results:

  • Both embryonic and adult stem/progenitor cells (from pancreas, liver, spleen, bone marrow) show potential for differentiation into insulin-producing cells.
  • Significant controversy and challenges persist regarding efficacy and safety.
  • Strategies like genetic engineering of hematopoietic stem cells are emerging.

Conclusions:

  • Stem cell-based therapies hold promise for type 1 diabetes but require substantial further research.
  • Overcoming immune system challenges is critical for successful clinical translation.
  • Preventive strategies using stem cells are also under investigation.