Preparation of an enteric-soluble solid-state emulsion using oily drugs

Area of Science:

• Pharmaceutical Technology
• Drug Delivery Systems
• Formulation Science

Background:

• Oily drugs often exhibit poor stability in gastric fluid, leading to reduced patient compliance.
• Developing stable oral formulations for oily drugs remains a challenge in pharmaceutical science.

Purpose of the Study:

• To develop an enteric-soluble solid-state emulsion (ESE) for improved stability and patient compliance of oily drugs.
• To investigate the preparation parameters influencing residual volatile oil and drug release from the ESE.

Main Methods:

• Liquid oil-in-water emulsions were spread and dried on a flat glass at 40°C.
• Aerosil 200 was used as a solid carrier and emulsifier.
• Eudragit L30D-55 served as the enteric coating material.

Main Results:

• The prepared zedoary turmeric oil (ZTO) ESE formed a stable emulsion in phosphate buffer (pH 6.8) within 20 minutes.
• Drug release was significantly suppressed when the ESE was exposed to simulated gastric fluid.
• Preparation parameters influenced residual volatile oil content and drug release profiles.

Conclusions:

• The developed method for preparing enteric-soluble solid-state emulsions is feasible for oral oily drug delivery.
• ESE technology offers a promising approach to enhance the stability and efficacy of oily drugs.
• This formulation strategy can potentially improve patient compliance for oral oily medications.