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Related Experiment Video

Updated: Jul 16, 2026

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

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Published on: July 9, 2016

Histamine and schizophrenia.

Jean-Michel Arrang¹

¹INSERM, U573, Unité de Neurobiologie et Pharmacologie Moléculaire, Centre Paul Broca, 2 ter rue d'Alésia, 75014 Paris, France.

International Review of Neurobiology

|March 14, 2007

Summary

Histamine neurons play a key role in brain functions like arousal and cognition. Research suggests these histamine neurons may be implicated in schizophrenia, with potential therapeutic targets identified.

Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Histaminergic neurons are crucial for regulating arousal, cognition, and energy balance.
Recent advancements in experimental tools have enhanced understanding of these neuronal functions.
Growing evidence suggests a potential role for histaminergic pathways in schizophrenia.

Purpose of the Study:

To explore the involvement of histaminergic neurons in the pathophysiology of schizophrenia.
To review current evidence linking histamine signaling to schizophrenia.

Main Methods:

Utilizing advanced tools like receptor ligands and genetically modified mice.
Investigating the effects of psychostimulants and NMDA-receptor antagonists on histamine neuron activity.
Examining the impact of antipsychotic medications on histaminergic systems.

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Last Updated: Jul 16, 2026

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

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Evaluating the efficacy of H3-receptor antagonists/inverse agonists in animal models of schizophrenia.

Main Results:

Hyperactivity of histamine neurons is observed in rodent models of schizophrenia.
Antipsychotic drugs modulate histamine neuron activity.
H3-receptor antagonists/inverse agonists show antipsychotic-like effects in preclinical models.
Evidence for histamine neuron involvement in schizophrenia is largely indirect due to limitations in human studies.

Conclusions:

Histaminergic neurons are strongly implicated in the control of arousal, cognition, and energy balance.
While evidence is indirect, histamine neurons appear to play a role in schizophrenia.
Targeting the histaminergic system, particularly H3 receptors, shows promise for novel antipsychotic therapies.